Selective IgA Deficiency is type of primary immunodeficiency characterized by a very low level of immunoglobulin A (IgA) in the blood, mucosal layer and secretions. The IgA antibodies play an important role in protecting us from infections in the blood and mucosal areas. Common problem in Selective IgA Deficiency is the person’s susceptibility to various infections such as recurrent ear infections, sinusitis, bronchitis, pneumonia, asthma, and food allergies are the most common infections seen in patients. Some patients also have gastrointestinal infections and chronic diarrhea since the deficiency of IgA onto mucosal surfaces. These infections may become chronic and may not completely clear with treatment, and the subjects may have to remain on antibiotics for longer term as the antibiotic such as prophylaxis is needed to keep them free from infections. Asthma may be more severe, and less responsive to the therapy, in individuals with IgA deficiency.