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Age-related macular degeneration (AMD) has become the leading cause of irreversible central vision loss in the elderly, affecting approximately 7.2 million people in United States over the age of 40 (6.5%). AMD is also the third leading cause of blindness globally, after cataracts and glaucoma. Most patients with AMD gradually start to lose central vision after age 60,and though many individuals are affected by the disease, treatment options are few. Currently, new treatment development is limited by a lack of understanding of AMD pathogenesis and is complicated by its late onset, complex genetics, and the influence of environmental risk factors such as age, smoking, and diet.
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