Rheumatoid Arthritis (RA) is a common condition. The more recent auto antibodies for the diagnosis of RA are anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies). Anti-CCP testing is particularly useful in the diagnosis of RA and it is able to predict the severity of the disease and the irreversible damage. Anti-CCPs have recently been added as one of the criteria in the 2010 American College of Rheumatology (ACR) /European League against Rheumatism (EULAR) classification of RA. Some studies have shown that anti- CCP antibodies are moderately sensitive but highly specific for the diagnosis of RA, and their specificity is higher than RF. It is claimed that the presence of anti-CCP antibody in a patient could be the sign of RA with a rate of 90-95%.