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Murine B cell development is a leading developmental system for the analysis of gene-regulatory networks that orchestrate cell fate choice and lineage commitment. Since progenitor cells and discrete developmental intermediates can be isolated and experimentally manipulated, the lymphoid system is particularly well suited for studies involving epigenetic, transcriptional, and protein networks that control cell fate choice. The analyses of early B cell development are thus highly advanced, as regulatory networks of signaling molecules and transcription factors have been elucidated that endeavor to account for the generation of B lineage progeny from multi-potent progenitors (MPP).
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