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Corneal neovascularization (CNV) results from the growth of new vessels from the limbal vasculature into the normally avascular cornea. As the second cause of severe visual impairment worldwide, it represents a major clinical problem. This occurs because CNV often leads to corneal opacification, thus reducing visual acuity. CNV is a well characterized and complex process, which includes different aspects of the corneal tissue: degradation of the epithelial basement membrane, remodeling of the extracellular matrix (ECM), and proliferation of endothelial cells.
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