Conditions that damage or overwork the heart muscle can cause heart failure. Heart weakens overtime.It will not be able to fill with and/or pump blood as well as it should.As the heart weakens overtime it releases certain proteins and substances into the blood which causes toxic effect on the heart and blood flow, and they worsen heart failure.Some common causes for heart failre coronary heart disease (CHD), high blood pressure, diabetes, Cardiomyopathy, Heart valve disease, Arrhythmias, Congenital heart defects,Treatments for cancer, such as radiation and chemotherapy, thyroid disorders, alcohol abuse or cocaine and other illegal drug use HIV/AIDS Too much vitamin E.