alexa Chemokine Deregulation in HIV Infection

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Chemokine Deregulation in HIV Infection

One of the hallmarks of AIDS is the progressive decline in CD4+ T cells in peripheral blood of HIV-infected individuals. This review focuses on how HIV-1 modulates inflammatory molecules, especially C-X-C chemokine ligand 10 (CXCL10), a Th1-chemoattractant chemokine to establish infection. HIV-infected T-cells, lead by Th1- agonist chemokines, gain access to the LNs where they die upon activation. The resultant T-cell death positively correlates with severe immunodeficiency and deteriorating HIV-1-infected patient’s health.


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