alexa TIM-3 and Its Immunoregulatory Role in HIV Infection

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TIM-3 and Its Immunoregulatory Role in HIV Infection

The chronic nature of Human Immunodeficiency Virus Type 1 (HIV) infection leads to the functional exhaustion of HIV specific CD8+ T cells. Although multiple markers of exhaustion have been identified so far, the recently discovered T cell immunoglobulin and mucin domain 3 (TIM-3) molecules distinguishes bona fide exhausted T cells with replicative senescence and functional impairment.


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