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The chronic nature of Human Immunodeficiency Virus Type 1 (HIV) infection leads to the functional exhaustion of HIV specific CD8+ T cells. Although multiple markers of exhaustion have been identified so far, the recently discovered T cell immunoglobulin and mucin domain 3 (TIM-3) molecules distinguishes bona fide exhausted T cells with replicative senescence and functional impairment.
Citation: https://www.omicsonline.org/tim-3-and-its-immunoregulatory-role-in-hiv-infection-2155-9899.S7-007.php?aid=10297
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