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Every year, influenza occurs globally with an attack rate estimated at 5-10% in adults and 20-30% in children, causing thousands of hospitalizations, especially among the elderly, young children, immuno-compromised individuals or subjects affected by chronic diseases at increased risk of developing complications. Worldwide, annual epidemics are estimated to result in about 3 to 5 million cases of severe illness and about 250,000 to 500,000 deaths. Influenza virus is an enveloped virus belonging to the Orthomyxoviridae family, characterized by a negative-sense, single-stranded and segmented RNA genome, that possesses eight segments encoding 10 well-known proteins, and other novel proteins identified in the last years.
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