Influenza type A virus (Influenza virus A), an old foe of mankind, is presently the most significant pathogen causing both pandemics and epizootics, worldwide. The proliferative husbandry of poultry and pigs, primarily, constitutes a key factor in ongoing generation of pandemic and pre-pandemic strains, which is fueled by remarkable wild aquatic bird permissiveness of the virus. Those attributes are here thoroughly inquired into, so as to profile and rate threat and usability. Also, various human interventions and misuses, including human experimental infections, undesirable vaccinations, as well as unauthorized and unskillful operations, led to bad corollaries and may rather be reassessed and modified or disallowed. Diversified interfaces between influenza and human manners are thereby brought out and elucidated, along with their lesson.