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Autoimmune hemolytic anemia is caused by hemolysis induced by the reaction of autoantibodies with red blood cells. Events that lead to AIHA include extravascular hemolysis caused by phagocytosis of erythrocyte-bound IgG in the spleen, activation of polyclonal B cells, reactions induced by molecular mimicry of exogenous antigens, breakdown of immune tolerance, and abnormal cytokine expression.