alexa Cell Biology of Mycobacterium tuberculosis

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Cell Biology of Mycobacterium tuberculosis

The fate of Mtb in the macrophage is one of the most intriguing aspects of Mtb pathogenesis and deserves explanation before a discussion of virulence factors. Mtb interacts with macrophages through multiple phagocytic receptors. Although macrophage responses to Mtb ligation of any or all of these receptors in vivo are unclear, some in vitro studies show that the ligation of particular receptors may determine the macrophage response. For instance, ligation of the Fc receptor (FcR) led to production of reactive oxygen intermediates (ROIs) and phagosomal-lysosomal fusion, whereas ligation of complement receptor 3 (CR3) or mannose receptor (MR) inhibited the respiratory burst and prevented phagosomal maturation.

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