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Multiple sclerosis is a inflammatory demyelinating illness of the central nervous system showed morphologically by irritation, demyelination, axonal misfortune and gliosis. The pathological feature highlight of the sclerotic MS plaque is demyelination. Both the myelin sheath and the oligodendrocyte itself are devastated inside lesions, following assault by cells of the invulnerable framework that re-demonstration with myelin-related epitopes, for example, myelin essential protein. Insusceptible assault includes both cell immunity, with T cells coordinated at myelin and oligodendrocytes and impelling phagocytosis by macrophages, Demyelinated plaques can likewise be seen in the cortical and subcortical grey matter.
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