The era of post identified information has begun, focusing on bioinformatics and systems biology. Large consortia as the HUPO BPP are necessary for such complex interdisciplinary research to overcome the problem of the necessary amount of data for biological interpretation in a system biology driven way. The gained complementary result lists as a part of the telephone book will be interpreted by systems biological means to overcome static identification lists. These efforts have to be based on comprehensive differential analyses using complementary methods and common standards. Only by combining several techniques (MS, ISH, ProteinBiochips etc.) and results from several Omics an understanding of e.g. complex brain diseases will be possible in the near future. The HUPO BPP and HUPO itself will elaborate suitable standards to collect data of many laboratories to build the mandatory fundaments of systems biology driven approaches and will help actively to realise these insights. However, the academic scientific research today needs barrier free data and publication access beside money, courage and self-criticism to bear new outstanding ideas.
Citation: Christian S, Michael H, Helmut EM (2008) How to Solve Complex Scientific Challenges with Comprehensive Proteomics and Bioinformatics means - HUPO Brain Proteome Project. J Proteomics Bioinform 1: 001-002. doi: 10.4172/jpb.1000001