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According to the National Institutes of Health (NIH), a biomarker is an objectively measured and evaluated indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to therapeutic intervention. Biomarkers serve as a valuable and attractive tool in the detection, risk assessment, diagnosis, prognosis, and monitoring of disease. The discovery of saliva-based microbial, immunologic, and molecular biomarkers offers unique opportunities to bypass painful invasive procedures by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Microbial Biomarkers potentially utilized beyond evaluating pathologies of the oral cavity.
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