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In the past, toxicologists relied on exposures of chemicals and biological agents to rodents, primarily rats, to determine LD50 (lethal dose 50%), dose response curves and to a lesser extent, reproductive and embryonic toxicities. This research provided a great deal of information, but that information is somewhat limited in its applicability to non-mammalian species as well as the ability of these data to address questions concerning the effects of contamination of aquatic ecosystems. To this end, more recent research has emphasized use of various fish species to carry out investigations of environmental toxicology.
For More Information: https://www.omicsonline.org/open-access/selecting-optimal-animal-models-to-investigate-environmental-toxicology-pfw.1000e102.php?aid=11842
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