American cranberry (Vaccinium macrocarpon) is naturally adapted to environments with high concentrations of soluble iron. Yet, there is a need to further explore iron nutrition in cranberry given concerns of toxicity problems from irrigation with iron-rich water. This study investigated the threat of iron toxicity by evaluating its effects on shoot growth total shoot weight, length (primary shoot and axillary growth), and number of axillary shoots in cranberry plants exposed to varying levels of a commonly used chelated iron, specifically Sequestrene 330 (ferric diethylenetriamine penta-acetate; Fe-DTPA). Cranberry plants were grown under controlled greenhouse conditions and received varying concentrations of Fe-DTPA in their irrigation water solutions. Four treatments of Fe-DTPA were applied (0, 14 ppm, 28 ppm, 56 ppm Fe), and shoot growth measurements were taken weekly over the course of 20 weeks. At the end of the course, total fresh shoot weight was recorded for each plant and tissues were sampled for nutrient analysis. Overall, shoot length (primary shoot and axillary) was significantly (P<0.05) reduced with increasing Fe-DTPA concentrations and plant symptoms included leaf drop, necrosis, and mortality in the higher concentration treatments.