Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability. Hemodynamic abnormality and disruption of white matter (WM) integrity are significant components in the pathophysiology of multiple sclerosis (MS) lesions. However, the roles of stratified lesions with distinct degrees of hemodynamic and structural injury in disease states remain to be explored. the hypothesis that hemodynamic and structural impairment, as assessed by cerebral blood volume (CBV) and fractional anisotropy (FA), respectively, characterizes the extent of tissue injury, and the load of lesion with substantial tissue destruction tests are to be done. Although the pathogenesis of the disease is not yet fully understood, hemodynamic abnormality and disruption of white matter (WM) integrity are associated with the pathological processes and contribute to the appearance of MS lesions.