Neonatal toxicity is the major complication during pregnancy. Anecdotal reports that attribute these syndromes to drug exposure must be cautiously interpreted, and larger samples must be studied in order to establish a causal link between exposure to a particular medication and a perinatal syndrome.Congenital malformations are the most common side effects during pregnancy. Long term medications during pregnancy causes severe side effects. Patient given with a long term psychotropic drug affects the nervous system of the baby.Long term exposure to the drugs like antidepressants result in poor neonatal outcomes and also persistent pulmonary hypertension in newborn. Nonetheless, the likelihood that a woman exposed to benzodiazepines during the first trimester will give birth to a child with this congenital anomaly, although significantly increased, remains less than 1%.