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The mechanism of fluoride ions [F-] to inhibit or even reverse the initiation and progression of dental decay, an infectious oral caries disease, is well documented. Fluoride ions are available in different forms; fluoridated water, milk or salt for public dental prevention; and fluoride drops, tablets, rinses, foams, gels and varnishes for individual caries prevention. Fluoride varnishes, with the typical high concentration of 22,600 parts per million fluoride, were developed to prolong the contact time between fluoride and the tooth surfaces, thereby improving the uptake of fluoride by the tooth surfaces. However, the more important mechanism of action of these varnishes is the interaction with saliva to form calcium fluoride (CaF2) compounds. These calcium fluoride deposits act as a prolonged source of fluoride ions to be released slowly to the oral environment. Thus, fluoride works both for the inhibition of the demineralization i.e. preventing the loss of tooth minerals as well as remineralization to rebuild the lost tooth minerals. READ MORE