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Obesity is a chronic multifactorial disease, which results from the interaction between the genotype and the environment. It has become a public health problem across the world, with significant physical and psychological complications that contribute to the deterioration of the quality and expectancy of life. Gastric bypass is the most effective treatment option for the management of morbid obesity. Surgical treatment of obesity could reduce excess body weight by 50%-70% when compared to behavioral and pharmacological therapies. However, Gastrojejunal stricture (GYS) is the most common complication after laparoscopic gastric bypass, being that the pathophysiological mechanism involved not well understood.