In 2011, 1.7 million college-age adults age 18 to 25 used prescription drugs for non-medical purposes, the second highest group for this type of abuse. Recently, New Hampshire (NH) prioritized AI as an evidence-based strategy for prescription drug abuse prevention. The purpose of this study was to investigate whether AI could effectively engage a college campus to decrease prescription drug abuse among its students. A study was performed at a NH college in 2013 involving 47 college students, faculty, administrators, and community partners. Central to the process was the concept of AI, a participatory research method that enables communities to discover its strengths, enhance interconnections, and use social capital to tackle significant issues.