alexa Preventive Action of Honey on Methotrexate Induced Intestinal Mucositis in Albino Rats

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Preventive Action of Honey on Methotrexate Induced Intestinal Mucositis in Albino Rats

Gastrointestinal mucositis (“mucositis”), is a form of mucosal barrier injury, occur as a severe side effect of many anticancer treatments. Unfortunately such therapy affects all rapidly dividing cells whether neoplastic or not. Since intestinal epithelial cells divide rapidly, chemotherapy can disrupt the intestinal epithelial barrier, leading to mitotic arrest in the crypts and villous blunting. Clinically the use of these drugs is often limited due to its side effects such as severe nausea and widespread gastrointestinal ulceration resulted in diarrhea as a main clinical characteristic [1]. Mucositis increases the morbidity of the patients undergoing cancer treatment, results in extended hospital stays and re- admission rates are also increased

 

 

Citation: Al-Refai AS (2014) Preventive Action of Honey on Methotrexate Induced Intestinal Mucositis in Albino Rats (Immunohistochemical Study). J Cytol Histol 5:265.

 
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