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Recurrent non-random chromosomal translocations are hallmark characteristics of leukemogenesis however molecular mechanisms underlying these rearrangements are less explored. The fundamental question is, why and how chromosomes break and reunite so precisely in the genome. Meticulous understanding of mechanism leading to chromosomal rearrangement can be achieved by characterizing breakpoints. To address this hypothesis, a novel multi-parametric computational approach for characterization of major leukemic translocations within and around breakpoint region was performed. To best of our knowledge, this study is unique in finding the presence of Segmental Duplications (SDs) flanking breakpoints of all major leukemic translocation. Breakpoint islands were also analyzed for other complex genomic architecture and physico-chemical properties. Our study distinctly emphasizes on the probable role of SDs and various genomic features in the occurrence of breakpoints. Further, it also highlights potential features which may be playing a crucial role in causing double-strand breaks leading to translocation.
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