Methotrexate (MTX) is used for the therapy of a wide range of neoplastic disorders including acute lymphoblastic leukemia, non- Hodgkin’s lymphoma, breast cancer and testicular tumors . MTX treatment may reduce the number of attacks in patients with recurrent acute anterior uveitis . Recent literature reported that high dose of MTX regimens may be used in induction of abortion as well as liver cholestatic disorders . As methotrexate (MTX) is an anti-metabolite drug, it is widely used in the treatment of many diseases such as rheumatoid arthritis and psoriasis.
Citation: Ali MBM, Ashmawy MH, El-shaarawy EAA, Mohamed IA, El-Galil TIA (2014) Effect of Methotrexate on the Jejunum of Adult Albino Rat and the Possible Protective Role of Vitamin A: Histological and Immunohistochemical Study. J Cytol Histol 5:263.