alexa An Update on Microrna’s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

An Update on Microrna’s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

Micro RNAs is a family of highly conserved, single stranded 19- 23 nucleotide long noncoding endogenous RNAs which negatively regulate gene expression, either by inhibiting translation or by degrading largest mRNAs. Over 2000 unique miRNAs have been identified in humans. The miRNAs are initially transcribed as long RNA precursors termed primary miRNAs (pri-miRNAs) that require the RNAse III enzyme Drosha in the nucleus to trim them into premiRNAs The premiRNAs are characterized by a stemloop or hairpin structure of 70-100 nucleotides and are exported to the cytoplasm by the nuclear export factor exportin 5. The pre-miRNAs are subsequently cropped to become mature miRNA by another RNAse enzyme Dicer in the cytoplasm. Although our understanding of the specific roles of miRNAs in cellular function is only beginning, recent studies revealed that miRNAs play a pivotal role in the most critical biological events such as development, proliferation, differentiation, apoptosis, transductionand carcinogenesis.

Citation: Kaur KK, Allahbadia GN, Singh M (2015) An Update on Microrna’s and Metabolic Regulation with Future Therapeutic PotentialsRegarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders. J Health Med Informat 6:184. doi: 10.4172/2157-7420.1000184

  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
Top