alexa Importance of Gene Polymorphisms in Renal Transplant Patients to Prevent Post Transplant Diabetes

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Importance of Gene Polymorphisms in Renal Transplant Patients to Prevent Post Transplant Diabetes

Post transplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation due to the immunosuppressive therapy. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM and zinc also playsan important role in all process of insulin trafficking, i.e. synthesis, storage and secretion. Gene polymorphisms in the transcription factor 7-like 2 (TCF7L2) and zinc transporter protein member 8(SLC30A8) was reported to be associated with type 2 diabetes, possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2, SLC30A8 and PTDM in renal allograft recipients.

Citation:

Vattam KK, Movva S, Khan IA, Upendram P, Rao P, et al. (2014) Importance of Gene Polymorphisms in Renal Transplant Patients to Prevent Post Transplant Diabetes. J Diabetes Metab 5:463

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