alexa Effect of Pre-Transplant Red-cell Transfusion Events on Transplant Related Mortality and Overall Survival in Children with Leukemia Undergoing Hematopoietic Stem Cell Transplant

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Effect of Pre-Transplant Red-cell Transfusion Events on Transplant Related Mortality and Overall Survival in Children with Leukemia Undergoing Hematopoietic Stem Cell Transplant

Recent studies have shown that an elevated ferritin level prior to hematopoietic stem cell transplant (HSCT), serving as a surrogate marker of body iron load, is independently associated with transplant related mortality (TRM) and inferior overall survival (OS) in adult oncology patients.The generation of hydroxyl radicals catalyzed by non-transferrin bound iron (NTBI) and subsequent tissue damage is responsible for the toxicity of iron overload . In adults with hematologic malignancies, pre-transplantation transfusional iron overload, as measured by serum ferritin, is independently associated with transplant related mortality (TRM) and inferior overall survival (OS) following hematopoietic stem cell transplantation (HSCT)

Citation: Andrews J, Li R, Mertens AC, Horan J, Josephson CD, et al. (2014) Effect of Pre-Transplant Red-cell Transfusion Events on Transplant Related Mortality and Overall Survival in Children with Leukemia Undergoing Hematopoietic Stem Cell Transplant. J Bone Marrow Res 2:142.

 
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