Recent studies have shown that an elevated ferritin level prior to hematopoietic stem cell transplant (HSCT), serving as a surrogate marker of body iron load, is independently associated with transplant related mortality (TRM) and inferior overall survival (OS) in adult oncology patients.The generation of hydroxyl radicals catalyzed by non-transferrin bound iron (NTBI) and subsequent tissue damage is responsible for the toxicity of iron overload . In adults with hematologic malignancies, pre-transplantation transfusional iron overload, as measured by serum ferritin, is independently associated with transplant related mortality (TRM) and inferior overall survival (OS) following hematopoietic stem cell transplantation (HSCT)
Citation: Andrews J, Li R, Mertens AC, Horan J, Josephson CD, et al. (2014) Effect of Pre-Transplant Red-cell Transfusion Events on Transplant Related Mortality and Overall Survival in Children with Leukemia Undergoing Hematopoietic Stem Cell Transplant. J Bone Marrow Res 2:142.