Aging causes a slow deterioration of the brain function leading to cognitive decline, memory loss, movement disorders and finally to functional decline and death. With a rapidly increasing aging population, neurodegenerative diseases such as Alzheimer′s, Parkinson′s and Huntington′s become an important economic burden on the society. Unfortunately, there are no effective current therapies. Therefore, it is quite urgent to find strategies that will lead to therapeutic benefits for the patients. Since aging is the major risk factor for the age-related neurodegenerative disorders, interfering with age-related molecular mechanisms or pathways might be an avenue to develop new therapeutics.