Introduction: Chromosomal Heteromorphisms are the inherited variations at specific chromosomal regions without a proven impact on the phenotype of an individual. Material and Methods: We studied and compared the chromosome Heteromorphisms in the Karyotypes of two groups. The first group consisted of 320 individuals of 160 couples with more than two miscarriages and no live birth and the second group consisted of 412 individuals of 206 normal couples with more than 1 normal child birth. Results and discussion: Twenty Nine individuals (9.06%) with a history of recurrent pregnancy loss were found to have chromosomal heteromorphisms, whereas thirteen individuals (3.1%) from the normal group were having the chromosomal heteromorphism. The difference between the two groups was statistically significant (p<0.0001) Conclusion: These results are consistent with other similar studies that suggest the yet undefined relationship between chromosome heteromorphism and recurrent pregnancy loss.