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mmune checkpoints constitute a distinctive set of proteins that belong to the B7 family. The engagement of these transmembrane receptors with their ligands provides critical signals to inhibit T cell activation and promote for immune tolerance. Tumor and infected cells can hide from the immune system by overexpressing these proteins, leading to T cell exhaustion.
For more details: https://www.omicsgroup.org/journals/immune-checkpoints-inhibitors-a-single-antiviral-and-anticancer-magicbullet-2376-0419-1000e127.php?aid=44945