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The mechanism that ectopic expression of germline genes result in somatic tumors such as melanoma and brain tumors remains a big challenge. A century of unproductive concentration on the cancer- is -a- cell-based -disease. Somatic Mutation Theory of carcinogenesis (SMT), the paradigmatic instability is coming to eyes, for instance, the tissue level [e.g. the Tissue Organization Field Theory of carcinogenesis (TOFT)] has been repeatedly suggested as one competitive strategy. Most recently, at the genome regulatory network level (GRN), the cancer attractors hypothesis naturally explains tumorigenesis, but such a new network-based intellectual framework is still quite abstract and also remains incompletely understood what its evolutionary origin is and what causes normal somatic cells be entrapped in.
Citation: Zhang Y (2011) New Concepts of Germline Gene -reactivated Cancer. Human Genet Embryol 1:e101. doi: 10.4172/2161-0436.1000e101
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