The mechanism that ectopic expression of germline genes result in somatic tumors such as melanoma and brain tumors remains a big challenge. A century of unproductive concentration on the cancer- is -a- cell-based -disease. Somatic Mutation Theory of carcinogenesis (SMT), the paradigmatic instability is coming to eyes, for instance, the tissue level [e.g. the Tissue Organization Field Theory of carcinogenesis (TOFT)] has been repeatedly suggested as one competitive strategy. Most recently, at the genome regulatory network level (GRN), the cancer attractors hypothesis naturally explains tumorigenesis, but such a new network-based intellectual framework is still quite abstract and also remains incompletely understood what its evolutionary origin is and what causes normal somatic cells be entrapped in.