alexa CT scanning protocol in washin/washout method to reduce the effect of xenoninduced flow activation on xenon-enhanced computed tomography calculations: cerebral blood flow and partition coefficient

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Recommended Conferences

2nd Global Meeting on Oncology and Radiology

Dubai, UAE
CT scanning protocol in washin/washout method to reduce the effect of xenoninduced flow activation on xenon-enhanced computed tomography calculations: cerebral blood flow and partition coefficient

Background: It has been required to reduce the effect of xenon-induced flow activation (Xe activation) in xenonenhanced computed tomography (Xe-CT). The goal of this work was to propose a CT scanning protocol in the washin/washout method that could reduce the Xe-activation effect on calculated cerebral blood flow (CBF) and partition coefficient (lambda) in Xe-CT. Methods: In the 4-min washin/4-min washout protocol with 1-min interval scans, the effect of Xe activation was calculated by theoretical simulations under the following scanning protocols based on the reported transcranial Doppler measurements: A: 1-min intervals, B: skip scans during the first 2 min in washout, and C: no scan in washout. For ten healthy subjects, CBF and lambda for the cortical regions of the right and left middle cerebral artery (MCA) territories were evaluated in protocols A and B. Results: Due to Xe activation, simulated CBF for gray matter was changed by 13%, 7% and 6%; simulated lambda for gray matter was changed by 2%, 4% and 4%; simulated CBF for white matter was changed by 11%, 10% and -1%; and simulated lambda for white matter was changed by 14%, 14% and 133% in protocols A, B and C, respectively. For the ten subjects, the mean differences between protocols A and B in obtained CBF were 1.85 (P=0.0337) and 2.23 mL/100g/min (P=0.0077), and those in obtained lambda were -0.042 (P<0.0001) and -0.041 (P<0.0001) for the right and left MCA territories respectively. This demonstrated that gray matter CBF by protocol A was statistically larger than that by protocol B, and gray matter lambda by protocol A was statistically smaller than that by protocol B, which agreed with the theoretical simulation results.

Citation: Sase S, Nakano H, Honda M (2015) CT scanning protocol in washin/washout method to reduce the effect of xenon-induced flow activation on xenon-enhanced computed tomography calculations: cerebral blood flow and partition coefficient. OMICS J Radiol 4:182.

  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
Top