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In the proliferative stage of diabetic retinopathy neovascularization is seen to occur on and adjacent to the disc (NVD) and also elsewhere in the retina (NVE). The bleeding from these vessels results in preretinal and vitreous hemorrhage causing severe visual loss. The Diabetic Retinopathy Study (DRS) identified certain high-risk characteristics, the presence of which predisposes these eyes to the risk of Severe Visual Loss (SVL).
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