Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Pull the Trigger, it Fires: The Critical Role of Insulin-Stimulated Caveolin-1 Tyrosine 14 Phosphorylation in Regulation of Insulin Trans-Endothelial Transport
In order for insulin to exert its biological actions on target cells in peripheral tissues like muscle and adipose tissues, Insulin must pass through the endothelial barrier into the interstitium.Insulin’s trans-endothelial transport (TET), particularly in muscle where capillaries are lined by a continuous endothelium, determines tissue insulin levels, and thereby critically determines insulin’s metabolic effects [1-6]. This process is significantly impaired in insulin resistance states such as obesity and type 2 diabetes [2,7-9]. Current evidence obtained by us and others indicate that insulin TET is transcellular process and mediated by transporting caveolae that contain or associate with multiple structural and signaling molecules including the insulin receptor (IR), IGF-1receptor, caveolin-1, dynamin-2, actin filaments and eNOS
- Share this page
