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Smart and advanced nucleic acid recognition process involving Peptide Nucleic Acid (PNA), aptamers can augment the efficiency of DNA based biosensors. PNA is a DNA analogue in which sugar phosphate backbone is replaced with pseudo peptide. PNA is composed of repeating N-(2-aminoethyl)-glycine units linked by peptide bonds. The unique structural hybridization and sensing feature of solution phase PNA can be readily extrapolated onto transducer surface to fabricate highly sensitive biosensor.
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