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Topical decongestants such as xylometazoline give good temporary relief from pregnancy rhinitis, but they tend to be overused, leading to the development of rhinitis medicamentosa. Decongestants are rapidly absorbed and there is concern that local vasoconstriction may cause placental insufficiency or exacerbate hypertension of pregnancy. Topical phenylephrine has been linked to fetal eye and ear malformations and club foot. Oxymetazoline has no significant systemic absorption and has less sympathomimetic effects than other topical preparations.
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