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Liver Biopsy in Type 2 Diabetic Patients

A liver biopsy is a procedure that involves taking a small piece of liver tissue for examination with a microscope for signs of damage or disease. 

Liver function tests (LFTs) are commonly used in clinical practice to screen for liver disease, monitor the progression of known disease, and monitor the effects of potentially hepatotoxic drugs.

Liver disease occurring as a consequence of diabetes mellitus
  • Glycogen deposition
  • Steatosis and nonalcoholic steatohepatitis (NASH)
  • Fibrosis and cirrhosis
  • Biliary disease, cholelithiasis, cholecystitis
  • Complications of  therapy of  diabetes (cholestatic and necroinflammatory)

Diabetes, by most estimates, is now the most common cause of liver disease in the U.S. Individuals with type 2 diabetes have a higher incidence of liver function test abnormalities than individuals who do not have diabetes. Mild chronic elevations of transaminases often reflect underlying insulin resistance. 

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