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Acute lymphoblastic leukemia (ALL) is the most common diagnosed cancer in children, constituting nearly one fourth of all pediatric malignancies and 80% of pediatric leukemia’s. The most common complications include stroke, posterior reversible leukoencephalopathy syndrome (PRES), temporal lobe epilepsy, highdose methotrexate toxicity, syndrome of inappropriate antidiuretic hormone secretion, and other abnormalities.