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Acinetobacter baumannii, a ubiquitous aerobic Gram-negative bacterium with high propensity to multi-drug resistance is a worldwide concern because of its dramatic increase over the past few decades, particularly in the setting of intensive care unit. The continuing debate surrounds the question of whether it is simply colonization with little clinical relevance or requires eradication because of its potential pathogenicity.In the obvious cases of active infection, such as overt pneumonia or multiple sites isolation especially from blood of A. baumannii, the decision to treat A. baumannii is usually straightforward. The dilemma occurs when A. baumannii is being isolated in the respiratory specimens of patients lacking evidence of active or ongoing lung infections, normally considered as a colonization that does not require eradication.
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