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Painless and painful crises are common phenomena in sickle cell disorder which is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin. It is an inherited autosomal recessive genetic disorder of hemoglobin (Hb) structure caused by point mutation at the sixth position in beta globin chain, valine substituting glutamic acid. The affected person inherits 2 mutant globin genesone is always the sickle mutation (abnormal haemoglobin structure). This leads to periodic episodes of pain and damages the vital organs. Sickle red cells die after only about 10 to 20 days, instead of the usual 120 days. Because they cannot be replaced fast enough, the blood is chronically short of red cells, thereby, causing anemia.
Gender Differences in Sickle Cell Crises: Implications for Genetic Counseling and Psychotherapy
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