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Obesity is a world-wide epidemic and available anti-obesity drugs are associated with side-effects. The effects of oral administration of a novel hybrid lipid obtained by conjugating fatty acid and α-lipoic acid esterified on a glycerol molecule, 1,3-dilauroyl-2-lipoyl-ital-glycerol (diLaLA), on the body weight and food intake of DIO male mice, as well as some other selected metabolic parameters in such mice, was investigated. DIO mice groups on an HFD were fed diLaLA in doses of 10, 50 or 250 mg/kg/day (DIO-10, -50 or -250) for 6 weeks. A fourth group of mice fed with the vehicle (rapeseed oil) alone and served as the control (DIO-V). In comparison with the DIO-V, the highest dose of diLaLA (DIO-250) significantly reduced the body weight, plasma and hepatic Free Fatty Acids (FFAs), as well as the SCD-16 activity index (C16:1n-7/C16:0) in the white adipose tissue of the DIO mice, whereas the liver weight was similar among all the groups. For more information, regarding the article, kindly go through the above link.
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