alexa Rats with Adjuvant Arthritis

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Rats with Adjuvant Arthritis

Rheumatoid arthritis (RA) is a chronic degenerative, systemic inflammatory disorder, most probable of autoimmune origin, characterized by chronic inflammation of multiple joints, with disruption of joint cartilage and structure due to destructive effects of a variety of pro-inflammatory cytokines and chemokines. The role of inflammatory chemokines and cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukins (IL-1 β, IL-6); proinflammatory enzymes such as cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase (5-LOX) and matrix metalloproteinase (MMP-9) and adhesion molecules in the pathogenesis of arthritis is well documented. For more information regarding this article, kindly go through the above link.

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