Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterised by inflammation in the synovium, malaise, morning stiffness and fatigue. It is associated with progressive joint destruction and, depending on the severity, may be accompanied by systemic manifestations including lung disease, rheumatoid nodules, effects on the cardiovascular system and blood. The prevalence of RA, at 0.5–1%, is relatively constant in many populations but factors such as gender, race and smoking status can cause a variation in this prevalence rate. Patients with RA tend to undergo exacerbations and periods of remission. If left untreated, over the course of 10–20 years RA may lead to significant disabilities and a severe reduction in the patient’s quality of life. Despite some success in the study of the RA pathogenesis, the stabilization of its clinical features is difficult to obtain. In this case, various RA extra-articular manifestations, including the blood system, aggravate its course and significantly complicate the therapy efficiency and opportunities. For more information regarding the article, kindly go through the above link.