Schizophrenia and Bipolar Disorder are two psychiatric conditions of great interest in modern times, not only because of their prevalence in psychiatric practice, but because, if untreated by any means, both are associated with higher physical and mental comorbitites, loss in productivity and quality of life and even increase risk of death . Bipolar disorder is defined by alterations between episodes depression and mania/hypomania. Depression is characterized by predominant sadness, loss of will and action, weight changes, sleep changes and suicidal ideation. Mania and hypomania are characterized by sudden expansion of affect, mood elevation, inflated self-esteem, decreased need for sleep, increased speed of thought, and psychomotor agitation. The exact prevalence is still unknown (considered 2.1% by the World Health Organization). Bipolar disorder normally presents itself in early adulthood, and is correlated with physical and social risks, increasing risk of death by external causes, and suicide by 25% when compared with general population.
Citation: Prior SL, Gagliardi ART, Caseiro MM, Prior PL (2014) Metabolic Alterations Associated With Antipsychotic Useâ€“A Descriptive Study and Comparison between Haloperidol and Olanzapine in Schizophrenic and Bipolar Patients. J Pharmacovigilance 2:143.