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MYC is a transcriptional factor and a proto-oncogene that is frequently deregulated in a wide array of cancers. Myc family genes include MYC, MYCN and MYCL1, which encode nuclear phospho proteins and function as sequence specific transcription factors that regulate large number of genes [1]. All the MYC family members have been implicated in a wide variety of human hematological malignancies and solid tumors. Of all the Myc family proteins, the MYC transcription factor is extensively studied and has been defined as a global regulator. The genome wide location analysis and gene expression profiling disclosed that 15% of the genome is regulated by the MYC transcription factor [2,3]. Alterations in MYC expression are induced by multiple mechanisms, including translocations, gene amplification, point mutations, over expression and increased protein stability. The MYC regulated cellular processes include cell growth, proliferation, differentiation, cell cycle progression, cell metabolism and apoptosis. The recent studies demonstrate that MYC is also a master regulator of ribosome biogenesis [4].
Citation: Peddigari S (2014) MYC Transcriptomics. Transcriptomics 2:e105. doi: 10.4172/2329-8936.1000e105
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