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Alzheimer´s disease is a progressive neurodegenerative disorder characterized by irreversible impairment of cognitive and memory functions and physical deterioration. The etiology of AD is still largely unclear and thought to be a multifactorial process. Typically depositions of amyloid protein plaques between and neurofibrillary tangles within nerve cells can be detected. Theses processes stimulate microglia to produce immunological mediators, including proinflammatory cytokines and cytotoxic substances.
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