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Two monkeys were trained to practice a visually guided hand reaching task. After the monkeys mastered the task, separate muscimol injections were made into cerebellar Dentate Nucleus (DN) or primary motor cortex (M1) to inactivate the local neural activity during performance of the task. After unilateral injections made into the DN or the M1, significantly delayed initiation of hand movement was observed whether the monkeys used either hand to perform the task.
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