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The Fragile X-associated Tremor Ataxia Syndrome (FXTAS) is a neurodegenerative disorder. Individuals with FXTAS usually present with an intention tremor followed by gait ataxia within a year or two. In addition, patients often present with neuropathy associated with pain in the lower extremities; autonomic dysfunction including hyper or hypotension, urinary incontinence, fainting spells and impotence; Parkinsonism with mixed type tremors, rigidity and bradykinesia; and cognitive impairment affecting memory and executive function.
