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Germ cell toxicity is a fatal hazard that is associated with numerous chemicals as they intervene in some way with normal functioning of the reproductive system of the human males and females. Among the major substances that are toxic to developing reproductive systems some of the chemicals are as follows: • Heavy metals ( lead, mercury, manganese, cadmium, arsenic) • Organic solvents (benzene, toluene, xylene, vinyl chloride, trichloroethylene, phenols) • Persistent organic pollutants (POPs) (PCBs, dioxins, DDT, organo chlorine pesticides) • Hormonally active agents (plasticizers such as phthalate esters) • Pesticides (organophosphate and carbamate type) • Cigarette smoke